Six Benefits of Early Antiviral Therapy for AIDS

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One of the treatment methods for AIDS is to carry out antiviral treatment, and experts say that early antiviral treatment is conducive to reducing the mortality of patients. Let's take a look at the six benefits of early AIDS antiretroviral treatment.

At present, the advanced anti viral treatment guidelines for AIDS in developed countries all advocate that anti viral treatment should be started no matter how high the CD4+is, which is obviously different from the previous decision on when to start treatment based on the CD4+level. Early anti viral treatment has the following benefits:



1. Early implementation of antiviral therapy can promote the reconstruction of immune function

The recovery of CD4 cell count of AIDS patients after combined antiviral treatment can be divided into two stages. The first stage is a rapid growth period, which occurs in the first few months after treatment; The second stage is a slow growth stage, followed by a slow increase in CD4 cells. The increase in CD4 cells in the second stage is more important than in the first stage because it means true immune reconstitution. Some studies have shown that the level of CD4 before treatment determines whether patients can achieve good immune reconstitution, and those with high CD4+gain better immune reconstitution.


2. Early antiviral treatment can greatly reduce the risk of complications

Regardless of the duration of infection and the level of CD4 in patients, generally speaking, after HIV enters the body, it can cause multiple organ damage to the body. HIV infected people with viral hepatitis can make the disease progress more rapidly, including cirrhosis, hepatocellular carcinoma, and liver failure. Antiviral therapy can delay the progress of liver disease by rebuilding immune function, reducing immune activation, and inflammatory reactions. Cardiovascular diseases are also an important cause of death among HIV infected people, accounting for 10% of the causes of death among HIV infected people. Research has shown that these risks can be significantly reduced if antiviral treatment is carried out earlier.


3. Early treatment can reduce mortality

In recent years, a large number of studies have shown that early antiviral treatment can reduce the mortality of patients infected with HIV. Research results from Europe and North America show that the higher the baseline CD4 during treatment, the lower the risk of AIDS related diseases and deaths. For example, the risk of death starting treatment when CD4 is less than 25 is 4.35 times that of patients starting treatment when CD4 is greater than 350.


4. Early treatment does not increase the drug resistance of AIDS virus

Some people worry that early treatment is prone to drug resistance, which is actually unnecessary. Scientific research has also proven this. HIV is really easy to mutate, and the pressure of antiviral drugs will increase the mutation of the virus, which will lead to drug resistance of the virus. However, there will be no mutation and drug resistance without virus replication. Early antiviral treatment can control virus replication as soon as possible, but it is not easy to lead to virus resistance. This has also proven to be the case. A study from the UK found that 230 patients who received early treatment had a drug resistance rate of about 7% within 8 years, which was basically the same as the incidence of drug resistance in patients who did not receive early treatment, and there was no increase.


5. Early treatment can greatly reduce the risk of infection

The truth is actually very simple: After antiviral treatment, the viral load in the blood decreases significantly or even cannot be detected, and the viral load in the reproductive tract and other tissues decreases accordingly, reducing the risk of infection in high-risk situations. Early development of antiviral therapy as an effective prevention strategy has been supported by many studies.


6. Early implementation of antiviral treatment can reduce the damage caused by adverse drug reactions

A large number of clinical studies have proven that early treatment can greatly reduce the damage caused by drugs to the body. "Because the immune function of the body has not been severely damaged in the early stage, and the ability to clear the damage caused by drugs to oneself is strong, the adverse reactions produced by the body are relatively mild."


(Images from the internet)

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